Choriocarcinoma and similar trophoblastic diseases. Dose individualized. PO, IM:
15-30 mg/day for 5 days. May be repeated 3-5 times with 1-week rest period between courses.
Acute lymphatic (lymphoblastic) leukemia.
Initial: 3.3 mg/m2 (with 60 mg/m2 prednisone daily); maintenance: PO, IM, 30 mg/m2 2 times/week or IV, 2.5 mg/kg q 14 days.
Meningeal leukemia. Intrathecal: 12 mg/m2 q 2-5 days until cell count returns to normal.
Lymphomas. PO: 10-25 mg/day for 4-8 days for several courses of treatment with 7- to 10-day rest periods between courses.
Mycosis fungoides. PO: 2.5-10 mg/day for several weeks or months; alternatively, IM: 50 mg once weekly or 25 mg twice weekly.
Lymphosarcoma. 0.625-2.5 mg/kg/day in combination with other drugs.
Osteosarcoma. Used in combination with other drugs, including doxorubicin, cisplatin, bleomycin, cyclophosphamide, and dactinomycin. Usual IV starting dose for methotrexate: 12 g/m2; dose may be increased to 15 g/m2 to achieve a peak serum level of 10-3 mol/L at the end of the methot-rexate infusion.
Adults, usual: PO, IM, IV, 10-25 mg/week, continued until beneficial response observed. Weekly dose should not exceed 50 mg. Alternate regimens: PO, 2.5 mg q 12 hr for three doses or q 8 hr for four doses each week (not to exceed 30 mg/week); or PO, 2.5 mg daily for 5 days followed by 2 days of rest (dose should not exceed 6.25 mg/day). Once beneficial effects are noted, reduce dose to lowest possible level with longest rest periods between doses.
Initial: Single PO doses of 7.5 mg/week or divided PO doses of 2.5 mg at 12-hr intervals for three doses given once a week; then, adjust dosage to achieve optimum response, not to exceed a total weekly dose of 20 mg. Once response has been reached, the dose should be reduced to the lowest possible effective dose.
Was this article helpful?
Did You Know That Herbs and Spices Have Been Used to Treat Rheumatoid Arthritis Successfully for Thousands of Years Do you suffer with rheumatoid arthritis Would you like to know which herbs and spices naturally reduce inflammation and pain 'Treating Rheumatoid Arthritis with Herbs, Spices and Roots' is a short report which shows you where to start.