Classification Antihypertensive antianginal calcium channel blocking agent

See also Calcium Channel Blocking Agents.

Action/Kinetics: Amlodipine decreases myocardial contractility although this effect may be counteracted by reflex activity. CO is increased and there is a pronounced decrease in peripheral vascular resistance. Peak plasma levels: 6-12 hr. t1/2, elimination: 30-50 hr. 90% metabolized in the liver to inactive metabolites; 10% excreted unchanged in the urine.

Uses: Hypertension alone or in combination with other antihyper-tensives. Chronic stable angina alone or in combination with other antianginal drugs. Confirmed or suspected Prinzmetal's or variant angina alone or in combination with other antianginal drugs.

Contraindications: Cardiogenic shock, hypotension 90 mm Hg, 2nd or 3rd degree heart block, severe CHF, sick sinus syndrome. Special Concerns: Use with caution in clients with CHF and in those with impaired hepatic function or reduced hepatic blood flow. Safety and efficacy have not been determined in children.

Side Effects: CNS: Headache, fatigue, lethargy, somnolence, dizziness, lightheadedness, sleep disturbances, depression, amnesia, psychosis, hallucinations, paresthesia, asthenia, insomnia, abnormal dreams, malaise, anxiety, tremor, hand tremor, hypoesthesia, vertigo, depersonalization, migraine, apathy, agitation, amnesia. Oral: Dry mouth, thirst, gingival hyperplasia, altered taste. GI: Nausea, abdominal discomfort, cramps, dyspepsia, diarrhea, constipation, vomiting, flatulence, dysphagia, loose stools. CV: Peripheral edema, palpitations, hypotension, syncope, bradycardia, unspecified arrhythmias, tachycardia, ventricular extrasystoles, peripheral ischemia, cardiac failure, pulse irregularity, increased risk of MI. Dermatologie: Dermatitis, rash, pruritus, urticaria, photosensitivity, pe-techiae, ecchymosis, purpura, bruising, hematoma, cold/clammy skin, skin discoloration, dry skin. Musculoskeletal: Muscle cramps, pain, or inflammation; joint stiffness or pain, arthritis, twitching, ataxia, hyperto-nia. GU: Polyuria, dysuria, urinary frequency, nocturia, sexual difficulties. Respiratory: Nasal or chest congestion, sinusitis, rhinitis, SOB, dyspnea, wheezing, cough, chest pain. Ophthalmologie: Diplopia, abnormal vision, conjunctivitis, eye pain, abnormal visual accommodation, xe-rophthalmia. Miscellaneous: Tinnitus, flushing, sweating, weight gain, epistaxis, anorexia, increased appetite, parosmia.

Arthritis Joint Pain

Arthritis Joint Pain

Arthritis is a general term which is commonly associated with a number of painful conditions affecting the joints and bones. The term arthritis literally translates to joint inflammation.

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