Classification Antihypertensive antianginal calcium channel blocking agent

See also Calcium Channel Blocking Agents.

Action/Kinetics: Amlodipine decreases myocardial contractility although this effect may be counteracted by reflex activity. CO is increased and there is a pronounced decrease in peripheral vascular resistance. Peak plasma levels: 6-12 hr. t1/2, elimination: 30-50 hr. 90% metabolized in the liver to inactive metabolites; 10% excreted unchanged in the urine.

Uses: Hypertension alone or in combination with other antihyper-tensives. Chronic stable angina alone or in combination with other antianginal drugs. Confirmed or suspected Prinzmetal's or variant angina alone or in combination with other antianginal drugs.

Contraindications: Cardiogenic shock, hypotension 90 mm Hg, 2nd or 3rd degree heart block, severe CHF, sick sinus syndrome. Special Concerns: Use with caution in clients with CHF and in those with impaired hepatic function or reduced hepatic blood flow. Safety and efficacy have not been determined in children.

Side Effects: CNS: Headache, fatigue, lethargy, somnolence, dizziness, lightheadedness, sleep disturbances, depression, amnesia, psychosis, hallucinations, paresthesia, asthenia, insomnia, abnormal dreams, malaise, anxiety, tremor, hand tremor, hypoesthesia, vertigo, depersonalization, migraine, apathy, agitation, amnesia. Oral: Dry mouth, thirst, gingival hyperplasia, altered taste. GI: Nausea, abdominal discomfort, cramps, dyspepsia, diarrhea, constipation, vomiting, flatulence, dysphagia, loose stools. CV: Peripheral edema, palpitations, hypotension, syncope, bradycardia, unspecified arrhythmias, tachycardia, ventricular extrasystoles, peripheral ischemia, cardiac failure, pulse irregularity, increased risk of MI. Dermatologie: Dermatitis, rash, pruritus, urticaria, photosensitivity, pe-techiae, ecchymosis, purpura, bruising, hematoma, cold/clammy skin, skin discoloration, dry skin. Musculoskeletal: Muscle cramps, pain, or inflammation; joint stiffness or pain, arthritis, twitching, ataxia, hyperto-nia. GU: Polyuria, dysuria, urinary frequency, nocturia, sexual difficulties. Respiratory: Nasal or chest congestion, sinusitis, rhinitis, SOB, dyspnea, wheezing, cough, chest pain. Ophthalmologie: Diplopia, abnormal vision, conjunctivitis, eye pain, abnormal visual accommodation, xe-rophthalmia. Miscellaneous: Tinnitus, flushing, sweating, weight gain, epistaxis, anorexia, increased appetite, parosmia.

Osteoarthritis

Osteoarthritis

Thank you for deciding to learn more about the disorder, Osteoarthritis. Inside these pages, you will learn what it is, who is most at risk for developing it, what causes it, and some treatment plans to help those that do have it feel better. While there is no definitive “cure” for Osteoarthritis, there are ways in which individuals can improve their quality of life and change the discomfort level to one that can be tolerated on a daily basis.

Get My Free Ebook


Post a comment